Aerobick usa
We suggest that aging-related loss of AG leading to decreased synaptic plasticity and neuroprotection may accelerate tauopathy in individuals with amyloid burden. No such correlation was observed for CMRGlc or CMRO 2. Our findings demonstrate that in individuals with amyloid burden, lower AG is associated with higher tau deposition. This multitracer positron emission tomography study evaluated the relationship between AG, total glucose use (CMRGlc), oxygen metabolism (CMRO 2), tau, and amyloid deposition in 42 individuals, including those at preclinical and symptomatic stages of Alzheimer's disease. AG supports important functions including biosynthesis and neuroprotection but decreases dramatically with aging. Research of the human brain metabolism in vivo has largely focused on total glucose use (via fluorodeoxyglucose positron emission tomography) and, until recently, did not examine the use of glucose outside oxidative phosphorylation, which is known as aerobic glycolysis (AG). Louis, MO, USA Knight Alzheimer Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA Hope Center for Neurological Disorders, Washington University School of Medicine, St. 5 Department of Radiology, Washington University School of Medicine, St.4 Department of Neurology, Washington University School of Medicine, St.3 Department of Radiology, Washington University School of Medicine, St.Electronic address: 2 Department of Radiology, Washington University School of Medicine, St. 1 Department of Radiology, Washington University School of Medicine, St.